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KMID : 1189420120250010001
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2012 Volume.25 No. 1 p.1 ~ p.11
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Effects of Paeoniae radix alba(PRA) on Skin whitening and Elasticity using Melanoma cells
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Lee Jong-Cheol
Park Soo-Yeon
Choi Jeong-Hwa
Kim Jong-Han
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Abstract
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Objective: Paeoniae radix alba(PRA) can enrich the blood and regulate menstruation, astringe yin and arrest sweating, calm the liver and arrest pain. This study was designed to investigate effects of PRA on skin whitening and elasticity using melanoma cells.
Methods: In this experiment, effect of PRA on cell viability, inhibition of melanin synthesis and inhibitory effect on tyrosinase and elastase.
Results: 1. More than of PRA treated group showed lowered proliferation rates significantly compared to non-treated control group. 2. All of treated groups were lower levels of melanin synthesis respectively. 3. PRA did not show inhibitory effect on tyrosinase activities in vitro. But, PRA suppressed tyrosinase activities in B16F10 cells significantly. 4. PRA suppressed elastse type 1 activities in dose-dependent manner in vitro. But, PRA slightly suppressed elastase type 4 activities in vitro, and PRA also slightly suppressed elastase activities in vivo.
Conclusion: These results suggest that PRA can inhibit melanin synthesis through ihhibitory action on tyrosinase activity and inhibt elastase activity, and also suggest that these results can be used for the study on maintaining skin whitening or elasticity.
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KEYWORD
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Paeoniae radix alba(PRA), Skin whitening, Skin Elasticity, Melanoma cell
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